Splicer is a robot that was meant to protect the reserve, but due to the war, Splicer malfunctioned to instead transform animals and plants in the reserve to weird monsters, by splicing their DNA.
When first entering the Sanctuary, it warns you, telling you not to enter the planet. The player goes into the Sanctuary, to be turned into a werewolf by the robot.
The player later confronts Splicer and the Chimera, after being helped and trained by the Ranger, and restores Splicer back to normal, thus allowing the player to switch from werewolf to human and back, while also allowing the player to change their appearance and improve their werewolf abilities.
Splicer is not fought directly, but the Chimera instead is pitted with the player. In the fight, there is a timer, after which if the player does not kill the Chimera, the Chimera is turned into a rat and is defeated.
Although Splicer is a robot, the Ranger refers to her as a female. Splicer later joins the player, allowing them to alternate between werewolf and human.